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Synthesis and Telomeric G Quadruplex Stabilizing Ability

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Charge on Quadruplex Binding Affinity and Cell Proliferation G-Quadruplex Stabilizing Ligands: Effects of 5-N Positive 5-N-Methylated Quindoline .

5-N-Methylated Quindoline Derivatives as Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-N Positive Charge on Quadruplex Binding Affinity and Cell Proliferation ...

Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chains. | PubFac

PubFacts seeks to make the world's scientific research easy to locate, access, and collaborate on. ... Shogo Sasaki Tokyo Ariake University of Medical and Health Sciences

Selective G-quadruplex DNA Stabilizing Agents Based on Bisquinolinium and Bispyridinium Derivatives of 1,8-Naphthyridi

Selective G-quadruplex DNA Stabilizing Agents Based on Bisquinolinium and Bispyridinium Derivatives of 1,8-Naphthyridine ... Synthesis of G-quadruplex DNA Stabilizing Agentsa aReagents and conditions: (i) ammonium formate, Pd (10%)/C, MeOH, 6 h, rt 2 3 ...

HKU Scholars Hub: 5-N-methylated quindoline derivatives as telomeric G-quadruplex stabilizing ligands: Effects of 5-N positive charge on .

the ligands stacked on the external G-quartets and the positively charged 5-N atom could contribute to the stabilizing ability. ... 5-N-methylated quindoline derivatives as telomeric G-quadruplex stabilizing ligands: Effects of 5-N positive charge on en_US ...

Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole | Nucleic Acids Research | Oxford Academ

... 1 had a high binding affinity specific towards telomeric multimeric G-quadruplexes and possesses a remarkable multimeric G-quadruplex-stabilizing ability. IZNP-1 may accordingly have the potential to act as a favorable anticancer agent by ...

Molecules | Free Full-Text | Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chai

G-quadruplexes (G4s), which are structures formed in guanine-rich regions of DNA, are involved in a variety of significant biological functions, and therefore “sequence-dependent” selective G4-stabilizing agents are required as tools to investigate and ...

Interaction of Metal Complexes with G‐Quadruplex DNA - Georgiades - 2010 - Angewandte Chemie International Edition - Wiley Online Libra

Guanine‐rich sequences of DNA can assemble into tetrastranded structures known as G‐quadruplexes. It has been suggested that these secondary DNA structures could be involved in the regulation of several key biological processes. In the human genome ...

Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their .

Structure-activity relationship studies were carried out on macrocyclic hexaoxazole (6OTD) dimers, ... Minhas GS, Pilch DS, Kerrigan JE, LaVoie EJ, Rice JE. Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles. . 16 ...

Charge on Quadruplex Binding Affinity and Cell Proliferation G-Quadruplex Stabilizing Ligands: Effects of 5-N Positive 5-N-Methylated Quindoline .

5-N-Methylated Quindoline Derivatives as Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-N Positive Charge on Quadruplex Binding Affinity and Cell Proliferation ...

Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chai

molecules Article Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chains Yue Ma 1, Keisuke Iida 2, Shogo Sasaki 1, Takatsugu Hirokawa 3,4,5, Brahim Heddi 6,7, Anh Tuân Phan 7 and Kazuo Nagasawa 1,

Solution Structure of a G‐quadruplex Bound to the Bisquinolinium Compound Phen‐DC3 - Chung - 2014 - Angewandte Chemie International Edition .

Telomeric G-Quadruplex Structures and G-Quadruplex-Interactive Compounds, Telomeres and Telomerase ... Anh Phan and Kazuo Nagasawa, Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles, , , 24, 2, , . ...

Targeting G-quadruplex DNA structures in the telomere and oncogene promoter regions by benzimidazole‒carbazole ligands - ScienceDire

a much weaker stabilizing ability and selectivity for all the investigated quadruplexes. ... In contrast to the telomeric G-quadruplex forming sequence, the G-quadruplex-forming sequences in promoter regions are diverse and can fold into multiple G ...

Ligand-Induced Conformational Changes with Cation Ejection upon Binding to Human Telomeric DNA G-Quadruplexes | Journal of the American Chemical .

Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chains. Molecules 2019, 24 (2) ...

Synthesis and Spectroscopic Studies of the Aminoglycoside (Neomycin) Perylene Conjugate Binding to Human Telomeric D

Synthesis and Spectroscopic Studies of the Aminoglycoside (Neomycin)-Perylene Conjugate Binding to Human Telomeric DNA ... properties of its binding to human telomeric G-quadruplex DNA, 50-d[AG 3-(T 2 AG 3) 3](4),arereported that 3 preferentially binds ...

G-quadruplex - Wikiped

3D Structure of the intramolecular human telomeric G-quadruplex in potassium solution. The backbone is represented by a ... This causes replication of damaged and cancerous cells. For therapeutic advances, stabilizing the G-quadruplexes of cancerous cells . ...

Professor PHAN Anh Tu

... Heddi B., Phan A.T., Nagasawa, K. (2019) Synthesis and telomeric G-quadruplex-stabilizing ability of macrocyclic hexaoxazoles bearing three side chains ...

Novel FeII and CoII Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex D

Novel Fe II and Co II Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA ... Tan J.-H., et al. 5-N-methylated quindoline derivatives as telomeric G-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex. ...

Novel and Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex D

Bioinorganic Chemistry and Applications is a peer-reviewed, Open Access journal that publishes original research in the ... up of epiberberine alkaloid fluorescence by fluorophore-switching aptamer and stoichiometric targeting of human telomeric DNA G . 730 · ...

Stabilization of DNA G-Quadruplexes - Information and Library Network Cent

Chapter 6 103 telomere organization. Formation of G-quadruplex at telomeric end prevents telomere elongation and that way inhibiting the activity of telomerase enzyme which has generated maximum research interest (Balasubramanian et al, 2011). The concept ...

Interaction of Metal Complexes with G‐Quadruplex DNA - Georgiades - 2010 - Angewandte Chemie International Edition - Wiley Online Libra

Guanine‐rich sequences of DNA can assemble into tetrastranded structures known as G‐quadruplexes. It has been suggested that these secondary DNA structures could be involved in the regulation of several key biological processes. In the human genome ...

This article is part of the Nucleic acids: new life, new materia

analogues were evaluated for their ability to stabilize telomeric G-quadruplex DNA, some of which ... ligands.51–54 We previously reported a G-quadruplex stabilizing synthetic small molecule, based on a N,N′-bis(quinolinyl)pyri-dine-2,6-dicarboxamide scaffold ...